BRAIN TRAUMA FOUNDATION

For 30 years, Brain Trauma Foundation has been conducting innovative clinical research and developing evidence-based guidelines that improve outcomes for the millions of people who suffer from traumatic brain injuries every year. From concussion to coma, Brain Trauma Foundation’s expertise allows us to better educate athletes, coaches, families, and medical professionals for improved prevention, diagnosis, and treatment.

WHAT IS A TRAUMATIC BRAIN INJURY?

A traumatic brain injury (TBI) is caused by an external force to the head. This can happen anywhere, anytime, and to anyone in situations like sports games, car crashes, or falls. The result of these accidents can range in severity from concussion to coma. In the U.S. alone, emergency departments report approximately 2.2 million TBI visits each year, leading to more than 280,000 hospitalizations.

MYTHS VS. FACTS

Myth:
Medical professionals fully understand what a concussion is.
Fact:
Medical professionals disagree on how to diagnose a concussion. Historically symptoms, such as headache, have been used as a diagnostic tool. However, current research suggests that medical professionals should instead focus on important brain functions affected by a force to the head, such as attention and balance.
Myth:
Male athletes are more likely than female athletes to have a concussion.
Fact:
In many sports, female athletes are more likely to be concussed. For example, among high school athletes, research shows that female basketball players suffered 240% more concussions than males, and female soccer players suffered 40% more concussions than males.
Myth:
A concussion patient should stay in a dark room and limit brain and body activity.
Fact:
Previously, medical professionals often recommended rest following a concussion. However, current research indicates that early exercise improves concussion recovery.
Myth:
Helmets prevent concussions.
Fact:
Helmets prevent scalp injuries and skull fractures. A concussion results from a whiplash-type head motion. Only by restricting the motions of the neck can risk of concussion be reduced.
Myth:
The longer person is in a coma state the less likely they are to fully recover.
Fact:
Amount of time in a coma state is only one factor that affects recovery. Other factors can include, but are not limited to, age, severity of injury, location of injury, and level of health before injury.

CONCUSSION EDUCATION

Concussions have reached epidemic proportions. Estimates are that up to 3.8 million athletes a year suffer from concussion, though the majority are underreported and underdiagnosed. While many of these patients do recover quickly, there are dangers around the many myths and misconceptions people currently hold about concussions. Our ever expanding outreach is working to demystify and educate athletes, coaches, trainers, and families about the reality of concussions. One of the greatest, and least known, results of concussion is the impact on a person’s ability to pay attention, leaving them more prone to additional injury.

GUIDELINES

Incorporating evidence found in our ongoing clinical research, we collaborate with medical experts and organizations around the world to develop, update, and refine best practice guidelines for TBI. Results show that the implementation of TBI guidelines produces improved efficiency and outcomes for professionals and patients, beginning with the pre-hospital management phase and extending throughout long-term application of care.

RESEARCH

We constantly seek to improve the diagnosis and treatment of TBI. To do this, we lead the way in cutting-edge clinical research spanning the spectrum from concussion to coma. We partner with some of the most prestigious organizations, such as the United States Department of Defense, Stanford University, Oregon Health and Sciences University, and Portland State University, on research. This work ranges from looking at the use of quantitative measurements via virtual reality eye tracking to better assess concussions, to being part of a multi-institutional research consortium that seeks to provide a stronger evidence base for brain injury research.

Clinical Trials in TBI
Failure to establish intervention effectiveness for brain trauma in clinical trials is a primary feature of the current condition of our work. Fourteen years ago the Clinical Trials in Head Injury Study Group published a thoughtful summary of recommendations to improve the design and conduct of clinical trials in TBI. They encouraged (in part):

  • Identification and testing of specific (appropriate) subgroups of TBI patients
  • Standardized clinical management across centers
  • Independent monitoring of patient management and data quality
  • Parsimonious data collection
  • Identification of relevant outcome measures and adequate time to follow-up, and
  • Identification of clinically relevant effect size.

A useful exercise might be to examine the extent to which our community is adhering to these recommendations, and to fundamental tenets of evidence-based medicine, in the design and conduct of our current work.

New Research Approaches
It is reasonable to consider how different research designs might be used to identify which treatments work best, for whom, and under what circumstances. This is the possibility of Comparative Effective Research (CER), which is being promoted by funding agencies and adopted by large consortium efforts in the brain trauma research community. However, CER is still subject to many of the same vulnerabilities at the operational level, because it is accomplished using randomized controlled trials (RCTs) and observational studies. A transition to a new focus on CER must be accompanied by consistent adherence to evidence-based protocols.

Collaborations
There is a need for investigators to work together, share data, and pool resources in order to improve our efficiency at finding answers. Currently, funding agencies are requiring collaborative efforts among their grantees as a prerequisite to funding. In our efforts to successfully collaborate, we need to account for institutional barriers to financial collaborations, and for barriers in the mechanics of collaborations. Pooling data into large repositories requires resources, time, and cooperation across investigators, institutions, and disciplines that often exceed the scope of the project. Building the platform for the repository becomes the deliverable, rather than using the platform to enable answering the questions.

ABOUT

Brain Trauma Foundation is led by our founder and president, Dr. Jamshid Ghajar. In 1986, Dr. Ghajar set forth to translate neuroscience into effective solutions. In the 30 years since, Brain Trauma Foundation has saved or significantly impacted for the better, the lives of countless patients worldwide. With groundbreaking global partnerships, such as the Indian Head Injury Foundation (IHIF), South America FUNDCOMA, and the Open Society Foundation, Brain Trauma Foundation is ensuring its educational outreach and actionable guidelines are touching the lives and trauma centers of patients worldwide.

​Jamshid Ghajar MD, PhD​, FACS

President
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Kathleen Stevens

Chief Financial Officer
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Stephanie Kolakowsky-Hayner PhD, CBIST, FACRM

Chief Operating Officer
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Board of Directors

Chairman
Alan G. Quasha
François M. Chateau
Paul J. Manafort
Pamela J. Newman
Sarah Jessica Parker
George Soros
Elizabeth H. van Merkensteijn
Deborah Ward
Christina H. Wilson

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